Trifluoroacetic anhydride-sodium iodide reagent. Nature and applications

Facile acylation of glycerophosphocholine catalyzed by trifluoroacetic anhydride.

A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economica...

Chemistry of Pyrrolizines; Reactions with Cyanogen Bromide and Trifluoroacetic Anhydride

-Interaction of the pyrrolizine 3 with cyanogen bromide in a tetrahydrofuran/water mixture affords addition to the enamine double bond with formation of 5 which can be aromatized to 6 by silica gel. Reaction of 6 with cyanogen bromide in the same solvent mixture yields the indoline 8a which structure is proved in a chemic/d way by conversion of the product into the aldehyde 8(1. The different r...

Intravenous Sodium Iodide in Goitre

T was an eye-witness of the fruitful experiments conducted in the Headquarters Hospital of this district during 1924 by Lieut. E. A. Davies, t.m.d., and Assistant Surgeon Dr. P. Bell, r.M.D. (now Civil Surgeon). After taking over charge of this hospital I repeated these experiments on some patients of this subdivision and obtained good results. Unfortunately the Chins here do not consider goitr...

Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation.

Sodium iodide symporter (NIS) and thyroid.

idase (TPO) and incorporation into tyrosyl residues along the thyroglobulin (Tg) backbone. The thyroid hormones T3 and T4 are synthesized by coupling of two iodotyrosine residues and stored in the colloid. All of these steps are stimulated by pituitary-derived thyroid stimulating hormone (TSH), which interacts with the TSH receptor at the basolateral membrane of thyroidal cells, through the cAM...